Central nervous system

Anaesthesia is induced within 20-40 s after i.v. administration in otherwise healthy young adults. Transfer from blood to the sites of action in the brain is slower than with thiopental, and there is a delay in disappearance of the eyelash reflex, normally used as a sign of unconsciousness after administration of barbiturate anaesthetic agents. Overdosage of propofol, with exaggerated side-effects, may result if this clinical sign is used; loss of verbal contact is a better end-point. EEG frequency decreases, and amplitude increases. Propofol reduces the duration of seizures induced by ECT in humans. However, there have been reports of convulsions following the use of propofol and it is recommended that caution be exercised in administration of propofol to epileptic patients. Normally cerebral metabolic rate, CBF and intracranial pressure are reduced.

Recovery of consciousness is rapid and there is a minimal 'hangover' effect even in the immediate postanaesthetic period.

Turbo Metabolism

Turbo Metabolism

Forget Silly Diets-They Don't Work. Weight loss has got to be the most frustrating experience for many people, young and old alike. Eating foods that are just horrible, denying yourself foods you truly love and enjoy. Exercising, even though you absolutely hate exercising, and end up stiff as a board with no results.

Get My Free Ebook


Post a comment