Clonazepam

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Clonazepam is a benzodiazepine. The usual maintenance dose is 4-8 mg daily in divided doses. It is also available as an intravenous preparation which has a place in the management of status epilepticus.

Clonazepam is 90% protein-bound and undergoes hepatic metabolism with an elimination half-life of 30-40 h. The main disadvantage of clonazepam is its sedative effect. There is also a tendency to develop tolerance to its anti-epileptic activity, with an unfortunate rebound increase in seizure frequency when it is withdrawn.

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