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Clonazepam is a benzodiazepine. The usual maintenance dose is 4-8 mg daily in divided doses. It is also available as an intravenous preparation which has a place in the management of status epilepticus.

Clonazepam is 90% protein-bound and undergoes hepatic metabolism with an elimination half-life of 30-40 h. The main disadvantage of clonazepam is its sedative effect. There is also a tendency to develop tolerance to its anti-epileptic activity, with an unfortunate rebound increase in seizure frequency when it is withdrawn.

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Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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