Aptamers may serve as powerful binders to small molecules for many possible applications, e.g. as "domains" for allosteric ribozymes, for biosensors, for artifi-

cal riboswitches or fluorescence tagging. In addition to their ability to efficiently interact with polypeptides, other bio-macromolecules, viruses, or even cells, apta-mers are not only able to recognize small molecules with high specificity but also to differentiate between marginal differences within these small molecules. Apta-mers are able, for example, to distinguish between caffeine and theophylline or the two highly similar amino acids citrulline and arginine.

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