Due to its high spatial resolution and the development of dedicated scanners, PET/CT has become a rapidly growing field among the imaging modalities. PET, especially if combined with CT, has gained significant importance, in particular in the oncological field. In addition to small molecules and peptides, apta-mers are a promising technology in the PET field. There is continuous and increasing interest in using oligonucleotides for PET imaging, although convincing in vivo applications of this molecular class are still missing. With the existence of targeted aptamers such as TTA1, the potential of this class of molecules will further be studied in different in vivo models.

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