VEGF and Human Disease

In more recent years, the role of VEGF in human disease has become much better understood, and VEGF has emerged as a key candidate for therapeutic inhibition (Ferrara et al., 2003). Angiogenesis plays an important role in many diseases, therefore providing a unique opportunity to develop agents against a single target for a diverse set of applications in many fields of medicine. Therapeutic success has been found in the eye for several reasons. First, angiogenesis is central to a number of ocular diseases; second, the eye is an easily accessible and relatively closed system, allowing direct delivery of therapeutic levels of drug to exactly where it is required; and third, the eye permits direct, in vivo examination of blood vessels, which facilitates preclinical and clinical drug development.

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