The clinical manifestations of atopic dermatitis

Atopic Dermatitis Black Child Pictures

Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease related to other atopic symptoms like allergic rhinitis, allergic conjunctivitis, and asthma. AD usually starts before the age of 2 years and is the first of the atopic symptoms that shows clinical signs. Patients with AD have an increased risk of developing other atopic symptoms later in life. Both endogenous and exogenous factors interact in the development of clinical signs of the disease. Hereditary factors are...

Psychosomatic aspects of atopic dermatitis

Significance Neurosecratory

THE HISTORICAL DEVELOPMENT OF PSYCHOSOMATIC DERMATOLOGY Embryologically, skin and the central nervous system (CNS) have the same origin in the ectoderm and are functionally closely related. One speaks of the skin as 'reflecting the soul'. Skin is a communication organ and plays an important role in the development and socialization over a whole life span. Skin is sensitive to tactile stimuli and responds to emotional stimuli. Skin diseases have a direct influence on communication, physical...

Stria Distensae Genital

Severe Striae

Clinical aspects of glucocorticoid treatment The first report on the efficacy of topical steroids became available in 1952, when compound F (i.e. hydrocortisone) was documented to be effective in various dermatoses including the treatment of atopic eczema.1 Five decades of clinical documentation and the experience of many doctors have proven the usefulness of topical steroids, which together with emollients today still are the 'gold standard' of treatment for atopic eczema. Although hundreds of...

Elidel Cream Before And After Face Pictures

Pimecrolimus

Thomas A Luger, Martin Steinhoff, Anita Remitz, and Sakari Reitamo Two topical calcineurin inhibitors (TCIs), tacrolimus, and the ascomycin derivative pimecrolimus, have been developed for the treatment of atopic dermatitis (AD). Tacrolimus ointment (0.03 , 0.1 ) and pimecrolimus cream (1 ) are now commonly regarded as effective therapies for AD, and both compounds have been approved by the authorities of many countries for the treatment of this disease. Tacrolimus ointment is marketed with the...

The pathogenesis of atopic dermatitis

Langerhans Skin Cells Images

The skin is much more than just a protective coat and encounters a high number of antigens at the interface between the body and the surrounding environment.1,2 Atopic dermatitis (AD) is a chronic inflammatory skin disease, clinically and histologically very similar to contact dermatitis. AD can occur at any age and has a high prevalence in children. In past years, the rising interest in this disease has been forced by its increasing prevalence in Western societies and its contribution to the...

Epidermal barrier dysfunction in atopic dermatitis

Epidermal Skin Barrier Dysfunction

Michael J Cork, Simon Danby, Yiannis Vasilopoulos, Manar Moustafa, Alice MacGowan, Jibu Varghese, Gordon W Duff, Rachid Tazi-Ahnini and Simon J Ward Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyper-reactivity to environmental triggers that are innocuous to normal, non-atopic individuals.1 Major contributors to this hyperactivity are the many changes in the cutaneous and systemic immune responses in individuals with AD.2 One example is the production...