Conclusion

There are conflicting data in the literature about the role of fungi in AD. The colonization of the skin with Malassezia species, the subsequent sensitization to this yeast, and positive patch tests with Malassezia extracts in patients with AD are not convincing proofs for the relevance of this yeast in the pathogenesis of AD; it could be a result of the skin barrier defect in these patients. On the other hand phylogenetically conserved allergen structures such as manganese superoxide dismutase (MnSOD) are present in fungi and in human cells. Interestingly, IgE- and T-cell-mediated reactivity against Malassezia was found in patients with extrinsic as in patients with intrinsic AE and occurs specifically in AE patients.56 In a subset of patients with AD sensitization to Malassezia, MnSOD should result in enhancing skin inflammation due to a molecular mimicry and cross-reactivity between fungal and human proteins.53 Therefore fungi are not causative for the development of AD but may aggravate the skin disease in some patients. New double-blind, placebo-controlled clinical trials with sufficient numbers of patients with well-characterized AD must clarify which patients with AD have a significant benefit from an antifungal therapy.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

Get My Free Ebook


Post a comment