Drug Redistribution

Even though the termination of drug action is mainly accomplished by the processes of drug elimination that will be discussed below, temporal changes in the direction of distribution may contribute to the reduction of a drug's action. For example, highly lipid-soluble barbiturates such as thiopental rapidly cause anaesthesia after intravenous administration because the brain is also receiving a good supply of blood. Subsequently, thiopental enters other lipid-rich tissues that are poorly vascularized and perfused such as subcutaneus fat. The reduction of thiopental blood levels will favor the passage of the drug from the brain back to the blood. Thus the action of a single dose of thiopental is short-lasting.

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