GABAergic Hypofunction

Gamma-aminobutyric acid is the principal inhibitory neurotransmitter of the brain. There is considerable evidence for a decreased activity of the GABAergic system in patients with schizophrenia (Bunney et al., 1997; Selemon, 2001). Various studies have reported a decrease in GABA content, a decrease in GABA uptake sites, a decrease in the synthesizing enzyme for GABA (the 67 kd isoform of glutamic acid decarboxylase—GAD67), a decrease in the GABA transporter (GAT), and a concomitant up-regulation of GABAA receptors. A down-regulation of GABAergic activity may have wide-ranging effects since the columnar firing pattern of cortical neurons is determined by a fine balance of glutamatergic excitation and GABAergic inhibition. Cortical malfunction is one of the hallmarks of schizophrenia.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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