Following on studies demonstrating serotonergic abnormalities in FTD, Miller and colleagues (Swartz et al., 1997) have demonstrated that selective serotonergic reuptake inhibitors (SSRIs) may be helpful in the treatment of these patients' psychopathology. In one small study, patients treated with paroxetine showed significant improvements in behavioral symptoms, reflected by a reduction of caregiver stress (Moretti et al, 2003).

As no abnormality of the cholinergic system has been demonstrated in FTD, there appears to be no role for cholinesterase inhibitors in the treatment of FTD at this time.

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