Biomedical science has been driven in the eighteenth through the twentieth centuries by the promise to deliver lifesaving therapies against disease and to extend human life. Development of all branches of biomedical sciences, including cardiac electrophysiology, went through a periodic adherence to either reductionist or integration approaches. Cardiac electrophysiology strived to deliver therapy against arrhythmias, which are still responsible for one of four deaths in the industrialized world.

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