Conclusions

Atherogenic lipoproteins are generated in the circulation as a by-product of triglyceride transport. The LDLR system provides a mechanism for clearing these athero-genic lipoproteins from the circulation into the liver. Mutations in the receptor, its ligand, or the accessory protein(s) required for internalization of the receptor lead to severe hypercholesterolemia and atherosclerotic vascular disease. Once cholesterol is delivered to the liver, it can be excreted from the body via the bile. The ABCG5/ABCG8 transport complex appears to be a specific transporter that facilitates the excretion of cholesterol and other neutral sterols into the bile.

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