Chloroquine, once considered too toxic for humans, has been the antimalarial of choice for 40 years. Although a range of serious CNS effects has been documented during chloroquine therapy, the incidence is unclear. y Abnormal involuntary movements including torticollis, blepharospasm, and dystonic tongue protrusion have been reported during chloroquine therapy, especially in patients younger than 30 years of age. [i] Headache, nausea, and tinnitus with progressive hearing loss, optic nerve dysfunction, seizures, psychosis, mania, and myasthenic syndrome have also been reported.

When used chronically, as in rheumatoid arthritis, chloroquine has been implicated in the development of peripheral neuropathy, cranial nerve palsies, and myopathy. The peripheral neuropathy is a distal sensorimotor polyneuropathy that is reversible after drug withdrawal. [ii


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