Side effects due to azathioprine (the nitroimidazole derivative of 6-mercaptopurine) can be classified as toxic (myelosuppression, hepatotoxicity) and idiosyncratic (fever, rigors, arthralgias, pneumonitis, and gastrointestinal symptoms). Although the toxic effects are due to 6-mercaptopurine, the hypersensitivity reactions are believed to be caused by the nitroimidazole moiety.

Azathioprine toxicity can occur during long-term treatment of myasthenia gravis. y , y Among 104 treated patients with myasthenia gravis, side effects occurred in 35 percent and included, in decreasing frequency, hematological, 18 percent; gastrointestinal, 13 percent; infectious, 13 percent; and elevation of liver enzymes 6 percent. The medicine was discontinued temporarily in 11 percent of the patients. In five patients, a malignant tumor was diagnosed, but a causal relationship seemed likely in only one. y Neurological toxicity is rare with azathioprine. Two patients with recurrent meningitic reactions following azathioprine ingestion have been presented in the literature; they were being treated for lupus of the CNS. y

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook

Post a comment