CNS candidiasis occurs in patients who have undergone organ transplantation, those receiving chronic corticosteroid therapy, those with a prolonged stay in the intensive care unit requiring invasive monitoring devices, and those who are treated with broad-spectrum antibiotics. CNS infections due to Candida present as either meningitis or cerebritis from multiple small parenchymal abscesses. 'iieJ CNS infection due to Candida often occurs in conjunction with fungemia.[r;9] The majority of patients with CNS Candida infections have positive fungal blood cultures and are neutropenic. 'risJ Scattered, irregular ring-enhancing lesions surrounded by edema may be present on neuroimaging studies. A definitive diagnosis is made through CSF or tissue biopsy and culture. Standard therapy includes intravenous amphotericin B (0.5 to 0.7 mg/kg/d) plus flucytosine (100 mg/kg/d in four divided doses).
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