Cholesterol Lowering Agents Clofibrate

Clofibrate, an aromatic monocarboxylic acid, is capable of inducing myotonia in humans and experimental animals and is clinically significant because it is widely used to reduce serum triglyceride levels. The mechanism by which it induces myotonia is believed to be through a decrease in chloride conductance.


Lovastatin and pravastatin are HMG-CoA reductase inhibitors that are effective cholesterol-lowering agents used in the treatment of hypercholesterolemia. They can induce myotonia by blocking chloride channels on the muscle membrane. '74'

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