Intrastriatal Structure

The Parkinson's-Reversing Breakthrough

Treatment for Parkinson Disease

Get Instant Access

Within the striatum, there is a large neuronal matrix compartment, comprising approximately 80% of the striatum, and a smaller compartment interdigitated with the matrix and known as striosomes or patches. Both the matrix and striasomal neurons receive inputs from dopamine cells coming from the pars compacta of the substantia nigra. Both cell types send efferent projections to the GP e , and these cells all contain enkephalin. In contrast, however, the matrix population also sends efferents to the substantia nigra pars reticulata and the GP i , whereas the striasomal cells project in large part back to the pars compacta. These projection cells contain substance P and dynorphin. y

Figure 16-3 Schema of anatomical nuclei and pathways involving the basal ganglia. Black arrows represent excitation, and speckled arrows represent inhibition. Note the two primary pathways that leave the striatum-the "direct" pathway that flows monosynaptically to the GP and the "indirect" pathway that has intermediate synapses in the G and the subthalamic nucleus. GP = globus pallidus internal segment; GP = globus pallidus external segment; STN = Subthalamic nucleus; SNr = pars reticularis of the substantia nigra; SNc = pars compacta of the substantia nigra; thal = thalamus.

Was this article helpful?

0 0
Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook

Post a comment