An isolated lesion of Meyer's loop typically leads to a congruous or incongruous contralateral homonymous hemianopia denser superiorly (pie-in-the-sky defect), whereas lesions of the parietal lobe lead to defects more prominent inferiorly. In clinical practice, there is significant variation in these findings. Complete interruption of the optic radiations causes a dense homonymous hemianopia. Visual acuity is spared in unilateral lesions, but it can be impaired if bilateral lesions are present. Again, the pupillary responses are normal.
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