Primary Small Brain Size

Nongenetic insults (prenatal, perinatal, postnatal) Infectious

Vascular disruption, hypoxic-ischemic insult Irradiation

Toxins and teratogens



Trauma (including shaken baby syndrome)

Genetic conditions

Chromosomal disorders


Trisomy 21

Trisomy 13

5p-(cri du chat) syndrome

Metabolic and degenerative conditions with onset before completion of brain growth


Smith-Lemli-Opitz syndrome

Infantile neuronal ceroid lipofuscinosis

Chromosomal instability and premature aging disorders


Bloom's syndrome

Cockayne's syndrome

Nijmegen chromosome breakage syndrome

Monogenic or sporadic "syndromic" disorders


Cornelia de Lange's syndrome Meckel's syndrome Rubinstein-Taybi syndrome Also:

Microcephalia vera

Microcephaly "plus"

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