MBL is a multifunctional protein known to be exerting the following functions: i) initiation of the lectin pathway through the binding of carbohydrates; ii) opsonization of target structures; iii) modulation of inflammatory response; iv) promotion of apoptosis (Turner, 2003).
The initiation of the complement cascade is realized through the binding of the MBL lectin domains to sugar residues and the subsequent activation of the MASPs (Wong et al., 1999). Activated MASP-2 in turn activates C4 and C2, and from the cleavage products the classical pathway C3-convertase, the C4b2a protease complex is formed. MBL has been shown to bind to a variety of micro-organisms including bacteria, fungi, viruses and parasites (Neth et al., 2000; van Emmerik et al., 1994). Lectin pathway activation is especially important in early childhood in the window period when maternal antibodies are no longer found in the circulation and the self-
Was this article helpful?
WHAT IT IS A three-phase plan that has been likened to the low-carbohydrate Atkins program because during the first two weeks, South Beach eliminates most carbs, including bread, pasta, potatoes, fruit and most dairy products. In PHASE 2, healthy carbs, including most fruits, whole grains and dairy products are gradually reintroduced, but processed carbs such as bagels, cookies, cornflakes, regular pasta and rice cakes remain on the list of foods to avoid or eat rarely.