Physical Appearance

Brushfield Spots Images Trisomy

Down syndrome phenotype is the most distinctive physical appearance associated with an atrioventricular septal defect.73,258,400,414 In 1866 Down wrote, The face is flat and broad and destitute of prominence. The cheeks are round and extended laterally. The eyes are obliquely placed, and the internal canthi more than normally distant from one another. The palpebral fissure is very narrow. The lips are large and thick with transverse fissures. The tongue is long, thick, and is much roughened....