In this chapter, we have focused on small molecules and how a systematic generation and application of these can be expediently used to probe and discover biology, both in an academic setting and in the initial drug design and development process. We also discussed the application of chemical biology technologies in studies of proteins and how this has opened up new avenues in protein engineering and paved the way for studies of proteins in that has previously not been possible. Similar principles and technologies are applied in studies of nucleic acids and polysaccharides with great benefit for basic research, but likewise in the development of biologicals.
Chemical biology is a scientific discipline that has emerged primarily from chemical sciences to apply chemical tools and principles in studies of biological phenomena. However, chemical biology has evolved in recent years to include scientists from many other disciplines, particularly those that emanate from biological sciences, making chemical biology a truly interdisciplinary playing ground. Like other interdisciplinary sciences, such as nanoscience and synthetic biology, chemical biology will have a growing impact on science in general in the future.
Dobson, C. M.; Gerrad, J. A.; Pratt, A. J. 2001. Foundations of Chemical Biology, Oxford University Press, Oxford.
Morrison, K. L.; Weiss, G. A. 2006. The origins of chemical biology, Nat. Chem. Biol. 2: 3-6. Schreiber, S. L. 2005. Small molecules: The missing link in the central dogma, Nat. Chem. Biol. 1: 64-66. Schreiber, S. L.; Kapoor, T.; Wess, G., Eds. 2007. Chemical Biology, Wiley-VCH, Weinheim. Waldmann, H.; Janning, P. 2004. Chemical Biology, A Practical Course, Wiley-VCH, Weinheim.
Was this article helpful?