Conclusions

The design of peptides and peptidomimetics is often the first step of drug discovery. To obtain a useful peptide or peptide mimetics drug requires a multidisciplinary approach including chemical biology, biophysics, and biological approaches. It is necessary to be aware of all available information and design methods in order to begin such a drug discovery program. Several chemical, biophysical, and bioinformatics approaches have been discussed and need to be evaluated in conjunction with the results from the best possible and appropriate in vitro and in vivo assays. This multidisciplinary approach will be essential for the development of rational approaches to peptide-based drug design in the future.

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