Contents

8.1 Introduction to Peptides and Peptidomimetics 123

8.2 General Features of Peptide Structure 124

8.3 Design Considerations 124

8.3.1 Ligand-Based Design 125

8.3.1.1 Identifying Pharmacophore Elements 126

8.3.1.2 Conformation of the Pharmacophore 126

8.3.1.3 ß-Turn Peptidomimetics and Other Peptide Mimetics 131

8.3.1.4 Applying Computational and Biophysical Studies for Design 131

8.3.2 Design Based on the Biological Function 132

8.4 Modeling and Docking 133

8.5 Conclusions 133

Further Readings 133

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