Contents

10.1 Introduction 151

10.1.1 Essential and Nonessential Elements 152

10.2 Classification of Inorganic Pharmaceuticals 153

10.3 The Human Body and Bioinorganic Chemistry 154

10.4 Coordination Chemistry 155

10.4.1 Chelate Effect 155

10.4.2 Hard and Soft Acids and Bases (HSAB Principle) 155

10.4.3 Kinetics. Inert and Labile Complexes 156

10.4.4 Redox Reactions 157

10.5 Chelate Therapy 157

10.5.1 Selected Chelates 158

10.5.1.2 D-Penicillamine 158

10.5.1.3 EDTA 158

10.5.1.4 Desferrioxamine 159

10.6 Inorganic Chemistry and Pharmaceuticals 159

10.6.1 Alkali Metals 160

10.6.2 Alkaline Earth Metals 160

10.6.3 Iron and Cobalt 162

10.6.4 Platinum and Ruthenium 163

10.6.5 Copper, Silver, and Gold 166

10.6.6 Zinc 169

10.6.7 Antimony and Bismuth 169

10.7 Concluding Remarks 170

Further Readings 171

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