Distomer Possesses Harmful Effects

In some cases, it is known that the distomer produces harmful or undesirable side effects. Thus, dextromethorphan is used as a cough suppressant, while levomethorphan has antitussive properties but it is also an opioid narcotic (Figure 5.8). The harmful teratogenic side effects of the (S)-enantiomer of thalidomide have already been discussed (Section 5.4).

Dextromethorphan (cough supressant)

Levomethorphan (narcotic)

Dextromethorphan (cough supressant)

Levomethorphan (narcotic)

(fi)-Thaiidomide (sedative)

(S)-Thalidomide (teratogen)

(fi)-Thaiidomide (sedative)

(S)-Thalidomide (teratogen)

FIGURE 5.8 Examples of drugs where the distomer possesses harmful effects.

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