Further Readings

Boteju, L.W., Wegner, K., Qing, X., and Hruby, V.J. (1994) Assymetric synthesis of unusual amino acids: Synthesis of optically pure isomers of N-indole-(2-mesitylenesulphonyl)-b-methyltryptophan. Tetrahedron 50:2391. Cowell, S.M., Balse-Srinivasan, P.M., Ahn, J.M., and Hruby, V.J. (2003) Design and synthesis of peptide antagonists and inverse agonists for G protein coupled receptors. In Methods in Enzymology, eds. R. Iyengar and J.D. Hildesbrandt. New York: Academic Press.

Han, Y., Liao, S., Qiu, W., Cai, C., and Hruby, V.J. (1997) Total assymetric syntheses of highly constrained amino acids ß-isopropyl-2',6'-dimethyl-tyrosines. Tetrahedron Lett. 38:5135.

Hruby, V.J. (2002) Design peptide receptor agonists and antagonists. Nat. Rev. Drug Discov. 1:847-858.

Hruby, V.J., Al-Obeidi, F., and Kazmierski, W.M. (1990) Emerging approaches in the molecular design of receptor selective peptide ligands: Conformational, topographical and dynamic considerations. Biochem. J. 268:249-262.

Kazmierski, W.M., Urbanczyk-Lipkowski, Z., and Hruby, V.J. (1994) New amino acids for the topographical control of peptide conformation: Synthesis of all isomers of a, ß-dimethylphenylalanine and a, ß-dime-thyl-1, 2, 3, 4 tetrahydroisoquinoline-3-carboxylic acid of high optical purity. J. Org. Chem. 59:1789.

Liao, S. and Hruby, V.J. (1996) Assymetric synthesis of optically pure ß-isopropylphenylalanine: A new ß-branched unusual amino acid. Tetrahedron Lett. 37:1563.

Marshall, G.R. (1993) A hierarchical approach to peptidomimetic design. Tetrahedron 49:3547-3558.

Olson, G.L., Bolin, D.R., and Bonner, M.D. et al. (1992) Concepts and progress in the development of peptide mimetics. J. Med. Chem. 36:3039-3049.

Qian, X., Russel, K.C., Boteju, L.W., and Hruby, V.J. (1995) Stereoselective total synthesis of topographically constrained designer amino acids: 2', 6'-dimethyl-ß-methyltyrosines. Tetrahedron 51:1033.

Qiu, W., Soloshonok, V.A., Cai, C., and Hruby, V.J. (2000) Convenient, large-scale assymmetry synthesis of enantiomerically pure transcinnamylglycine and a-alanine. Tetrahedron 56:2577.

Sawyer, T.K. (1997) Peptidomimetic and non-peptide drug discovery: Impact of structure-based design. In Structural Based Drug Design, ed. P. Veerapandian, pp. 559-634. New York: Marcel Dekker, Inc.

Wang, S., Tang, X.-J., and Hruby, V.J. (2000) First stereoselective synthesis of an optically pure ß-substituted histidine: (2S, 3S) ß-methylhistidine. Tetrahedron Lett. 41:1307.

Wiley, R.A. and Rich, D.H. (1993) Peptidomimetics derived from natural products. Med. Res. Rev. 13:327-384.

Xiang, L., Wu, H., and Hruby, V.J. (1995) Stereoselective synthesis of all individual isomers of ß-methyl-2', 6'-dimethylphenylalanine. Tetrahedron 6:83.

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