Prehistoric drug discovery started with higher plant and animal substances, and this continues today to be a fruitful source of biologically active molecules frequently belonging to unanticipated structural types. Adding to the long list of classical plant products that are still used in modern medicine, one can list many substances of more recent origin, including antibiotics such as penicillins, cepha-losporins, tetracyclines, aminoglycosides, various glycopeptides, and many others (Chapter 25). Anticancer agents of natural origin comprise taxol, camptothecin, vinca alkaloids, doxorubicin, and bleomycin (Chapter 23). Among immunosuppressant agents, cyclosporine and tacrolimus deserve a special mention.
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