The Use of a Chiral Auxiliary

In this methodology a "chiral group" is purposefully attached to the achiral substrate solely for the purpose of controlling the stereochemical outcome of subsequent reactions. The unit chosen is not an integral part of the target compound, but instead is removed once it has performed its function. The advantage of this methodology is that the reaction of the chiral substrate (i.e., with auxiliary attached) produces a diastereomer. Therefore, even if a high level of induction in subsequent reactions is not produced the products can potentially still be separated to isolate the pure enantiomer.

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