Enzymes are nature's chiral catalysts, which are extremely versatile in catalyzing almost every known chemical reaction. It is now generally agreed that enzymes can accommodate a variety of structurally diverse substrates and some can be used under a wide variety of conditions, this being particularly applicable to the extremophile class of enzyme which can be isolated from microbes capable of surviving in extreme environments.
Enzymes catalyzing a wide variety of chemical reactions are available for enantioselective synthesis (Table 5.1) and thanks to the advent of molecular biological techniques the choice of enzyme is not restricted to those found in nature. High-throughput screening methods can be used to discover
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