Diazepam Binding Inhibitor

Another peptide that is produced by the human D cells is diazepam-binding inhibitor (DBI), which is an 86-amino acid peptide that binds to the benzodiazepine recognition site within the y-aminobutyric acid (GABA)-receptor complex.60 Immunocytochemical studies have localized DBI to D cells in human islets, although in rat islets the peptide seems to be confined to the A cells.61 Because DBI inhibits glucose-stimulated insulin secretion,6162 the two peptides produced by the D cells, somatostatin and DBI, both restrain insulin secretion, and a tempting speculation is that the role of the D cells is to inhibit B-cell activity, although, as previously stated, the islet paracrine concept has not been established.

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