Neurotensinoma

Pancreatic neuroendocrine tumors that secrete neurotensin have been reported.72'73 Neurotensin is a peptide that is present in the brain and the gastrointestinal tract.72 Neurotensin can cause hypotension, tachycardia, cyanosis, pancreatic secretion, intestinal motility, and small intestinal secretion.72 Patients with neurotensinomas have diarrhea with hypokalemia, weight loss, diabetes, cyanosis, hypotension, and flushing. Patients may be cured by tumor resection, and others have responded to chemotherapy.72'73 Some have questioned whether a separate neurotensinoma exists. Patients with VIPoma and gastrinoma have been found to have elevated plasma levels of neurotensin. At present, it is unclear whether a separate syndrome exists.

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