Pancreastatin

Another peptide that is produced by the islet B cells is pancreastatin, which is a carboxyterminal amidated

TABLE 78-1. Endocrine Peptides and Neuropeptides in the Istet Cells and Gastrointestinal Peptide Hormones Affecting Islet Cell Hormone Secretion

Effect on Insulin Effect on Glucagon

TABLE 78-1. Endocrine Peptides and Neuropeptides in the Istet Cells and Gastrointestinal Peptide Hormones Affecting Islet Cell Hormone Secretion

Effect on Insulin Effect on Glucagon

Source

Name

Abbreviation

Secretion

Secretion

Islet B cells

Insulin

Stimulatory/inhibitory

Inhibitory

Islet amyloid polypeptide

LAPP

Inhibitory

Inhibitory

Pancreastatin

Inhibitory

Stimulatory

Islet A cells

Glucagon

Stimulatory

Peptide YY

PYY

Inhibitory

Inhibitory

Islet D cells

Somatostatin

Inhibitory

Inhibitory

Diazepam-binding inhibitor

DBI

Inhibitory

Islet F cells

Pancreatic polypeptide

PP

Inhibitory

Gastric X cells

Ghrelin

Inhibitory

Duodenal K cells

Gastric inhibitory polypeptide

GIP

Stimulatory

Duodenal I cells

Cholecystokinin

CCK

Stimulatory

Heal L cells

Glucagon-like peptide 1

GLP-1

Stimulatory

Inhibitory

Islet adrenergic nerve

Galanin

Inhibitory

Stimulatory

terminals

Neuropeptide Y

NPY

Inhibitory

Norepinephrine

Inhibitory

Stimulatory

Islet cholinergic nerve

Vasoactive intestinal

VIP

Stimulatory

Stimulatory

terminals

polypeptide

Pituitary adenylate cyclase-

PACAP

Stimulatory

Stimulatory

activating polypeptide

Gastrin-releasing polypeptide

GRP

Stimulatory

Stimulatory

Acetylcholine

Stimulatory

Stimulatory

Islet sensory nerve

Calcitonin gene-related

CGRP

Inhibitory

terminals

polypeptide

Substance P

SP

Inhibitory

49-amino acid peptide initially purified from the pancreas and found to inhibit glucose-stimulated insulin secretion from the perfused rat pancreas.46 Pancreastatin is cleaved from chromogranin A before its storage in B-cell secretory granules.47 The peptide is released from the pancreas in parallel with insulin,48 inhibits insulin secretion, and stimulates glucagon secretion.49 The physiologic function of pancreastatin is not known.

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