Pancreatic Polypeptide

PP was first described as a contaminant of a chicken insulin extract.10 It is known today that the PP is produced by the pancreatic F cells. PP consists of a 36-amino acid sequence and is produced by cleavage from a 95-amino acid precursor.63 The F cells are particularly abundant in the ventral portion of the pancreas, where the F cells seem to replace the A cells in the mantle zone of the islet. Because PP secretion is stimulated by vagal activation, it has been suggested that plasma PP levels offer a good parameter for vagal activity.64 The peptide has been shown to inhibit the secretion of pancreatic juice and bile and to suppress insulin secretion,65,66 which might be of importance for interprandial homeostasis, although the physiologic role of PP is yet to be established.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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