Somatic Mutations

Although somatic mutations can occur in normally replicating cells, those with an increased proliferation rate have a higher risk of acquiring somatic mutations (i.e., allelic deletions of tumor suppressor genes and point mutations in oncogenes).6874-79 By the introduction of specific X chromosome probes, it has been shown that both nonendemic and endemic multinodular goiters contain polyclonal and monoclonal nodules.74 The clonal analyses have thus shown that a genetic mutation mechanism may play a major role in the formation of nodules in multinodular goiter. Cells with mutations that favor growth slowly clonally outgrow the other thyroid cells (Fig. 28-4).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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