Somatic Mutations

Although somatic mutations can occur in normally replicating cells, those with an increased proliferation rate have a higher risk of acquiring somatic mutations (i.e., allelic deletions of tumor suppressor genes and point mutations in oncogenes).6874-79 By the introduction of specific X chromosome probes, it has been shown that both nonendemic and endemic multinodular goiters contain polyclonal and monoclonal nodules.74 The clonal analyses have thus shown that a genetic mutation mechanism may play a major role in the formation of nodules in multinodular goiter. Cells with mutations that favor growth slowly clonally outgrow the other thyroid cells (Fig. 28-4).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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