Hypercalcemia is a common end-stage problem in patients with malignant neoplasms. Malignancy is the most common cause of hypercalcemia in hospitalized patients, whereas primary hyperparathyroidism is the most common cause of hypercalcemia in nonhospitalized patients. PTHrP is the most common cause of hypercalcemia in patients with cancer. There are now PTHrP assays to quantitate PTHrP levels. Unfortunately, there are no good means of treating patients with malignant tumors and high PTHrP levels, and most patients die within 8 weeks.


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fg.i r chapter 62

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