Carcinoid tumors are neuroendocrine tumors that frequently produce various hormones and kinins that may cause characteristic symptoms, including carcinoid syndrome. The symptoms, treatments, and prognosis depend mostly on the location and size of the tumor. Surgical resection can be palliative even when there is metastatic tumor. Somatostatin analogs can alleviate the symptoms of carcinoid syndrome.


1. Caplin ME, Buscombe JR., Hilson AJ, et al. Carcinoid tumour. Lancet 1998:352:799.

2. Habal N, Sims C, Bilchik AJ. Gastrointestinal carcinoid tumors and second primary malignancies. J Surg Oncol 2000;75:310.

3. Ganim RB, Norton JA. Recent advances in carcinoid pathogenesis, diagnosis and management. Surg Oncol 2000:9:173.

4. Capella C, Heitz PU, Hofler H, et al. Revised classification of neuroendocrine tumors of the lung, pancreas and gut. Virchows Arch 1995;425:547.

5. Jensen RT. Natural history of digestive endocrine tumors. In: Mignon M, Colombel JF (eds), Recent Advances in the Pathophysiology and Management of Inflammatory Bowel Diseases and Digestive Endocrine Tumors. Paris, John Libbey Eurotext, 1999, p 192.

6. Moertel CG, Sauer WG, Dockerty MB, et al. Life history of the carcinoid tumor of the small intestine. Cancer 1961;14:901.

7. Teitelbaum SL. The carcinoid. Am J Surg 1972; 123:546.

8. Oberndorfer S. Karzinoid Tumoren des Dünndarmes. Frankf Z Pathol 1907;1:425.

9. Masson P. Carcinoids (argentafßn-cell tumors) and nerve hyperplasia of the appendicular mucosa. Am J Pathol 1928;4:181.

10. Masson P. La glande endocrine de l'intestin chez l'homme. Coll R Acad Sei (Paris) 1914;158:59.

11. Warren KW, Coyle EB. Carcinoid tumors of the gastrointestinal tract. Am J Surg 1951;82:372.

12. Feyrter F. Über die periphen endokrinen (parakrinen) Drüsen des Menschen. Verlag für medizinische Wissenschaften. Wien-Düsseldorf, Wilhelm Maudrich, 1938.

13. Williams ED, Sandler M. The classification of carcinoid tumours. Lancet 1963;1:238.

14. Pearse AGE. The APUD concept and hormone production. Clin Endocrinol Metab 1980;9:211.

15. Pearse AGE. The APUD cell concept and its implication in pathology. Pathol Annu 1974;9:27.

16. Fontaine J, Le Dourain NM. Analysis of entoderm formation in the avian blastoderm by the use of quail-chick chimeras. J Embryol Exp Morphol 1977;41:209.

17. Bolande RP. The neurocristopathies: A unifying concept of disease arising in neural crest maldevelopment. Hum Pathol 1974;5:409.

18. Solcia E, Klöppel G, Sobin LH. Histological Typing of Neuroendocrine Tumors. Berlin, Springer, 2000.

19. Lauffer JM, Zhang T, Modlin IM. Review article: Current status of gastrointestinal carcinoids. Aliment Pharmacol Ther 1999;13:271.

20. Helpap B, Kollermann J. Immunohistochemical analysis of the proliferative activity of neuroendocrine tumors from various organs. Virchows Arch 2001;438:86.

21. Wheeler MH, Curley IR, Williams ED. The association of neurofibromatosis, pheochromocytoma, and somatostatin-rich duodenal carcinoid tumor. Surgery 1986;100:1163.

22. Jensen RT. Carcinoid and pancreatic endocrine tumors: Recent advances in molecular pathogenesis, localization, and treatment. Curr Opin Oncol 2000;12:368.

23. Görtz B, Roth J, Krahenmann AN, et al. Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms. Am J Pathol 1999;154:429.

24. Oberg K. Carcinoid tumors: Molecular genetics, tumor biology, and update of diagnosis and treatment. Curr Opin Oncol 2002; 14:38.

25. Calender A. New insights in genetics of digestive neuroendocrine tumors. In: Mignon M, Colombel JF (eds), Recent Advances in the Pathophysiology and Management of Inflammatory Bowel Diseases and Digestive Endocrine Tumors. Paris, John Libbey Eurotext, 1999, p 155.

26. Kulke MH, Mayer RJ. Carcinoid tumors. N Engl J Med 1999;340:858.

27. Bordi C, Corleto VD, Azzoni C, et al. The antral mucosa as a new site for endocrine tumors in multiple endocrine neoplasia type I and Zollinger-EUison syndromes. J Clin Endocrinol Metab 2001;86:2236.

28. Tonnies H, Toliat MR, Ramel C, et al. Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation. Gut 2001;48:536.

29. Lollgen RM, Hessman O, Szabo E, et al. Chromosome 18 deletions are common events in classical midgut carcinoid tumors. Int J Cancer 2001;92:812.

30. Kytola S, Hoog A, Nord B, et al. Comparative genomic hybridization identifies loss of 18q22-qter as an early and specific event in tumorige-nesis of midgut carcinoids. Am J Pathol 2001;158:1803.

31. Wilander E. Diagnostic pathology of gastrointestinal and pancreatic neuroendocrine tumors. Acta Oncol 1989;28:363.

32. Johnson LA, Lavin P, Moertel CG, et al. Carcinoids: The association of histological growth pattern and survival. Cancer 1983;51:882.

33. MacGillivray DC, Snyder DA, Drucker W. Carcinoid tumors: The relationship between clinical presentation and the extent of the disease. Surgery 1991;110:68.

34. Graham E, Smith DG. What is the cause of the carcinoid flush? Gut 1987;28:1413.

35. Wang LT, Wilkins EW, Bode HH. Bronchial carcinoid tumors in pediatric patients. Chest 1993;103:1426.

36. Teh BT. Thymic carcinoid tumors in multiple endocrine neoplasia type 1. Ann Surg 1998;228:99.

37. Frölich JC, Bloomgarden ZT, Oates JA, et al. The carcinoid flush. N Engl J Med 1978;299:1055.

38. Ohrvall U, Eriksson B, Juhlin C, et al. Method for dissection of mesenteric metastases in midgut carcinoid tumors. World J Surg 2000;24:1402.

39. Kaltsas G, Korbonits M, Heintz E, et al. Comparison of somatostatin analog and metaiodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors. J Clin Endocrinol Metab 2001;86:895.

40. Hoegerle S, Altehoefer C, Ghanem N, et al. Whole-body 18F dopa PET for detection of gastrointestinal carcinoid tumors. Radiology 2001;220:373.

41. Ahlman H, Wängberg B, Tisell E, et al. Clinical efficacy of octreotide scintigraphy in patients with midgut carcinoid tumours and evaluation of intraoperative scintillation detection. Br J Surg 1994;81:1144.

42. Moertel CG, Weiland LH, Telander L. Carcinoid tumor of the appendix in the first two decades of life. J Pediatr Surg 1990;25:1073.

43. Izbicki JR, Eypasch E, Seel R, et al. Zur Frage der chirurgischen Behandlung malinger Tumoren der appendix. Zentralbl Chir 1989; 114:1217.

44. Economopolous GC, Lewis JW, Lee MW, et al. Carcinoid tumors of the thymus. Ann Thorac Surg 1990;50:58.

45. Akerstrom G, Makridis C, Johansson H. Abdominal surgery in patients with midgut carcinoid tumors. Acta Oncol 1991;30:547.

46. Marshall JB, Bodnarchuk G. Carcinoid tumors of the gut. J Clin Gastroenterol 1993;16:123.

47. Agranovich AL, Anderson GH, Manji M, et al. Carcinoid tumor of the gastrointestinal tract: Prognosis factors and disease outcome. J Surg Oncol 1991;47:45.

48. Rindi G, Capella C, Solcia E. Pathobiology and classification of gut endocrine tumors. In: Mignon M, Colombel JF (eds), Recent Advances in the Pathophysiology and Management of Inflammatory Bowel Diseases and Digestive Endocrine Tumors. Paris, John Libbey Eurotext, 1999, p 177.

49. Schussheim D, Skarulis M, Agarwal S, et al. Multiple endocrine neoplasia type 1: New clinical and basic findings. Trends Endocrinol Metab 2001 ;12:173.

50. Cohen T, Gluzman-Poltarak Z, Brodzky A, et al. Neuroendocrine cells along the digestive tract express neuropilin-2. Biochem Biophys Res Commun 2001;284:395.

51. Delellis RA. Proliferation markers in neuroendocrine tumors: Useful or useless? Verh Dtsch Ges Pathol 1997;81:53.

52. Dotzenrath C, Goretzki P, Cupisti K, et al. Malignant endocrine tumors in patients with MEN 1 disease. Surgery 2001;129:91.

53. Mullan M, Gauger P, Thompson N. Endocrine tumors of the pancreas: Review and recent advances. ANZ J Surg 2001 ;71:475.

54. Schindl M, Kaserer K, Niederle B. Treatment of gastric neuroendocrine tumors. Arch Surg 2001; 136:49.

55. Makridis C, Rastad J, Oberg K, et al. Progression of metastases and symptom improvement from laparotomy in midgut carcinoid tumors. World J Surg 1996;20:900.

56. Hellman P, Lundström T, Öhrvall U, et al. Effect of surgery on the outcome of midgut carcinoid disease with lymph node and liver metastases. World J Surg 2002;26:991.

57. Federspiel BH, Burke AP, Sobin LH, et al. Rectal and colonic carcinoids. Cancer 1990;65:135.

58. Jetmore AB, Ray JE, Gathright JB, et al. Rectal carcinoids: The most frequent carcinoid tumor. Dis Colon Rectum 1992;35;717.

59. Ballantyne GH, Savoca PE, Flannery JT, et al. Incidence and mortality of carcinoids of the colon. Cancer 1992;69:2400.

60. Siperstein A, Berber E. Cryoablation, percutaneous alcohol injection, and radiofrequency ablation for treatment of neuroendocrine liver metastases. World J Surg 2001;25:693.

61. Jaeck D, Oussoultzoglou E, Bachelier P, et al. Hepatic metastases of gastroenteropancreatic neuroendocrine tumors: Safe hepatic surgery. World J Surg 2001 ;25:689.

62. Nave H, Mossinger E, Feist H, et al. Surgery as primary treatment in patients with liver metastases from carcinoid tumors: A retrospective, unicentric study over 13 years. Surgery 2001;129:170.

63. Olausson M, Friman S, Cahlin C, et al. Indications and results of liver transplantation in patients with neuroendocrine tumors. World J Surg 2002;26:998.

64. De Vries H, Verschueren RJC, Willemse PH, et al. Diagnostic, surgical and medical aspect of the midgut carcinoids. Cancer Treat Rev 2002;28:11.

65. Moertel CG, Johnson CM, McKusick MA, et al. The management of patients with advanced carcinoid tumors and islet cell carcinomas. Ann Intern Med 1994;120:302.

66. Therasse E, Breitmayer F, Roche A, et al. Transcatheter chemoem-bolization of progressive carcinoid liver metastases. Radiology 1993;189:541.

67. Proye C. Natural history of liver metastasis of gastroenteropancreatic neuroendocrine tumors: Place for chemoembolization. World J Surg 2001:25:685.

68. Arnold R, Trautmann ME, Creutzfeldt W, et al. Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumors. Gut 1996;38:430.

69. Skogseid B. Nonsurgical treatment of advanced malignant neuroendocrine pancreatic tumors and midgut carcinoids. World J Surg 2001; 25:700.

70. Mulvihill SJ. Perioperative use of octreotide in gastrointestinal surgery. Digestion 1993;54(Suppl 1):33.

71. Oberg K. Chemotherapy and biotherapy in neuroendocrine tumors. Curr Opin Oncol 1993;5:110.

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