The adrenal gland has two functioning endocrine units, the cortex and the medulla. The cortex secretes corticosteroids, including the major glucocorticoid, Cortisol, and the major mineralocorticoid, aldosterone. The cortex also secretes DHEA-S and, to a lesser extent, androgens and estrogens. Glucocorticoids are necessary for life, and their secretion is regulated by the hypothalamic-pituitary-adrenal axis. The medulla primarily secretes the catecholamines epinephrine, norepinephrine, and dopamine.


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