Are there different types of testosterone therapy

There are several different types of available testosterone therapies (Table 19).

Oral Testosterone Therapy

Currently, oral testosterone therapy is not used in the United States. In other countries, an oral form of testosterone (testosterone undecenoate) is available that is well-tolerated and provides more consistent testosterone levels.

Parenteral (Intramuscular) Testosterone Therapy

Parenteral testosterone is inexpensive and safe, but has several disadvantages. Use of parenteral testosterone requires periodic deep intramuscular (IM, into the muscle) injections, usually every 2 to 3 weeks. Use of testosterone injection therapy results in supraphysiologic (higher than normal) levels of testosterone, usually

Table 19 Comparison of Testosterone Replacement Therapies

Type Of Therapy

Frequency

Side Effects

Table 19 Comparison of Testosterone Replacement Therapies

INJECTABLE

Testosterone enanthate and Cypionate

100-400 mg

Q.l-4 weeks

• Supraphysiologic level 2-5 days after injection

• Peak may be associated with breast tenderness, gynecomastia, and mood swings.

• May affect spermatogenesis.

• Highest incidence of side effects

Less expensive

Testosterone pellets

Q_6 months

• Risk of erythrocyte sis

• 8.5% risk of pellet extrusion

Expensive

TOPICAL THERAPY

Androderm nonscrotal patch

12.2 mg patch delivers 2.5 mg/day;

24.3 patch delivers 5 mg/day

• 0.1% triamcinolone cream under reservoir decreases incidence and severity of skin reactions

Less expensive

Testoderm TTS nonscrotal patch

328 mg patch delivers 5 mg/day

• 3% erythema

Less expensive

Testoderm scrotal patch

4 mg and 6 mg patch

• 2% irritation

Less expensive

Androgel 1% testosterone gel

5 g (50 mg), 7.5g (75 mg), 10 g (100 mg) packet

Daily

• 5.6% application site reaction

Expensive

Transbuccal

30 mg

BID

• Most closely mimics normal circadian rhythm

• Gingival irritation

Very expensive

Reprinted from Urologic Nursing, 2008, Volume 28, Number 5, p. 366. Reprinted with permission of the publisher, the Society of Urologic Nurses and Associates, Inc. (SUNA), East Holly Avenue, Box 56, Pitman, NJ 08071-0056; (856) 256-2300; FAX (856) 589-7463; E-mail: [email protected]; Web site: www.suna.org.

Kj Kl

Reprinted from Urologic Nursing, 2008, Volume 28, Number 5, p. 366. Reprinted with permission of the publisher, the Society of Urologic Nurses and Associates, Inc. (SUNA), East Holly Avenue, Box 56, Pitman, NJ 08071-0056; (856) 256-2300; FAX (856) 589-7463; E-mail: [email protected]; Web site: www.suna.org.

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