What causes the PSA to rise

Anything that irritates or inflames the prostate can increase the PSA, such as a urinary tract infection, prostatitis, prostate stones, a recent urinary catheter or cystoscopy (a look into the bladder through a specialized telescope-like instrument), recent prostate biopsy, or prostate surgery. Sexual intercourse may increase the PSA up to 10%, and a vigorous rectal examination or prostatic massage before the PSA blood test is drawn may also increase the PSA. Benign enlargement of the prostate (BPH) may also increase the PSA because more prostate cells are present, thus more PSA is produced (see Question 3).

Prostate cancer is composed of both hormonesensitive and hormone-insensitive cells.

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