FIGURE 15.28 Biotransformation of aromadendra-9-one (80) by Curvularia lunata.

(+)-ent-Cyclocolorenone (98) [a]D - 405° (c = 8.8, EtOH), one of the major compounds isolated from the liverwort Plagiochila sciophila (Asakawa, 1982, 1995), was treated by Aspergillus niger to afford three metabolites, 9-hydroxycyclocolorenone (99, 15.9%) 12-hydroxy-(+)-cyclocolorenone (100, 8.9%) and a unique cyclopropane-cleaved metabolite, 6b-hydroxy-4,11-guaiadien-3-one (101, 35.9%), and 6b,7b-dihydroxy-4,11-guaiadien-3-one (102, trace), of which 101 was the major component. The enantiomer (103) [a]D + 402° (c = 8.8, EtOH) of 98 isolated from Solidago altissima was biotransformed by the same organism to give 13-hydroxycycolorenone (103a, 65.5%), the enantiomer of 100, 1b,13-dihydroxycyclocolorenone (103b, 5.0%), and its C11-epimer (103c)

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Aromatherapy Ambiance

Aromatherapy Ambiance

Aromatherapy, a word often associated with calm, sweet smelling and relaxing surroundings. Made famous for its mostly relaxing indulgent  feature, using aromatherapy has also been known to be related to have medicinal qualities.

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