FIGURE 14.14 Biotransformation of nerol (272) by Spodoptera litura. (Modified from Takeuchi, H. and M. Miyazawa, 2004. Proc. 48th TEAC, pp. 399-400.)
Catharanthus roseus converted (+)-linalool (206) to 8-hydroxylinalool (219) (Hamada et al., 2004) (Figure 14.15).
The biodegradation of (+)-linalool (206) by Pseudomonas pseudomallei (strain A), which grows on linalool as the sole carbon source, was described in 1973 (Murakami et al., 1973) (Figure 14.16).
Madyastha et al. (1977) isolated a soil Pseudomonad, Pseudomonas incognita, by the enrichment culture technique with linalool as the sole carbon source. This microorganism, the "linalool strain" as it was called, was also capable of utilizing limonene (68), citronellol (258), and geraniol (271) but failed to grow on citral (275 and 276), citronellal (261), and 1,8-cineole (122). Fermentation was carried out with shake cultures containing 1% linalool (206) as the sole carbon source. It was suggested by the authors that linalool (206) was metabolized by at least three different pathways of biodegradation (Figure 14.19). One of the pathways appeared to be initiated by the specific oxygenation of C-8 methyl group of linalool (206), leading to 8-hydroxylinalool (219), which was further oxidized to linalool-8-carboxylic acid (220). The presence of furanoid linalool oxide (215) and 2-methyl-2-vinyltetrahydrofuran-5-one (216) as the unsaturated lactone in the fermentation medium
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