Limonene Rowatinex

The Gallstone Elimination Report

Gallstone Natural Solutions by David Smith

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Source: Sybilska, D. and M. Asztemborska, 2002. J. Biochem. Biophys. Methods., 54: 187-195.

Source: Sybilska, D. and M. Asztemborska, 2002. J. Biochem. Biophys. Methods., 54: 187-195.

in fact they are different. The compositions have changed slightly over the years and the most recently disclosed are shown in Table 11.1.

Rowachol has been in use for over 50 years for the dissolution of gallstones and biliary tract stones. There have been many published works on its effects and at least one double-blind trial (Lamy, 1967). It has been stated that although the dissolution rate of Rowachol is not impressive, it is still much greater than Rowatinex and could occur spontaneously (Doran and Bell, 1979). It has been employed alone as a useful therapy for common duct stones (Ellis and Bell, 1981) although improved results were demonstrated when Rowachol was used in conjunction with bile acid therapy (Ellis et al., 1981).

Rowachol has been shown to inhibit hepatic cholesterol synthesis mediated by a decreased hepatic S-3-hydroxy-3-methylgutaryl-CoA reductase activity (Middleton and Hui, 1982); the components mostly responsible for this activity were menthol and 1,8-cineole, with pinene and camphene having no significant effect (Clegg et al., 1980). A reduction in cholesterol crystal formation in the bile of gallstone patients has been demonstrated in a small trial using Rowachol (von Bergmann, 1987).

Two early uncontrolled trials reported that Rowachol significantly increased plasma high-density lipoprotein (HDL) cholesterol when administered to patients with low HDL cholesterol; a twofold increase was found in 10 subjects after 6 weeks of treatment (Hordinsky and Hordinsky, 1979), while a progressive increase in HDL of 14 subjects was noted, >100% after 6 months (Bell et al., 1980). This was interesting as low plasma concentrations of HDLs are associated with an elevated risk of coronary heart disease. However, a double-blind, placebo-controlled trial that administered six capsules of Rowachol daily for 24 weeks to 19 men found that there were no significant HDL-elevating effects of the treatment (Cooke et al., 1998). It is currently thought that monoterpenes have no HDL-elevating potential that is useful for disease prevention.

In vitro, a solution of 97% d-limonene was found to be 100-fold better at solubilizing cholesterol than sodium cholate. A small trial followed with 15 patients, whereby 20 ml of the d-limonene preparation was introduced into the gallbladder via a catheter on alternate days for up to 48 days. The treatment was successful in 13 patients with gallstone dissolution sometimes occurring after three infusions. Side effects included vomiting and diarrhea (Igimi et al., 1976).

A further study was conducted by Igimi et al. (1991) using the same technique with 200 patients. Treatments lasted from 3 weeks to 4 months. Complete or partial dissolution of gallstones was achieved in 141 patients, with complete disappearance of stones in 48% of cases. Epigastric pain was experienced by 168 patients and 121 suffered nausea and vomiting. Further trials have not been conducted.

11.5.2 Renal Stones

While Rowachol is used as a measure against gallstones and biliary tract stones, Rowatinex is used in the treatment of renal stones. The first double-blind, randomized trial was conducted by Mukamel et al. (1987) on 40 patients with acute renal colic. In the Rowatinex group, there was a significantly higher expulsion rate of stones >3 mm in diameter in comparison with the placebo (61% and 28%, respectively). There was also a higher overall success rate in terms of spontaneous stone expulsion and/or disappearance of ureteral dilatation in the treatment group compared to placebo (78-52%), but the difference was not statistically significant.

A second double-blind, randomized trial was conducted on 87 patients with ureterolithiasis. Four Rowatinex capsules were prescribed four times a day, the average treatment time being two weeks. The overall stone expulsion rate was significantly higher in the Rowatinex group as compared to placebo; 81% and 51%, respectively. Mild to moderate gastrointestinal disturbances were noted in seven patients. It was concluded that the early treatment of ureteral stones with Rowatinex was preferable before more aggressive measures were considered (Engelstein et al., 1992).

Rowatinex has also been used with success in the removal of residual stone fragments after extra-corporeal shock wave lithotriptsy, a situation that occurs in up to 72% of patients when given this therapy. With 50 patients, it was found that Rowatinex decreased the number of calculi debris, reducing the number of late complications and further interventions. By day 28, 82% of patients were free of calculi whereas this situation is normally reached after 3 months without Rowatinex treatment (Siller et al., 1998).

A minor study examined the use of Rowatinex in the management of childhood urolithiasis. Six children aged from 4 months to 5 years were administered varying doses of the preparation from 10 days to 12 weeks. All patients became stone-free with no side effects, although a definite conclusion as to the efficacy of treatment could not be established due to the small patient number involved (Al-Mosawi, 2005).

A comparison of the effects of an a-blocker (tamsulosin) and Rowatinex for the spontaneous expulsion of ureter stones and pain control was undertaken using 192 patients. They were divided into three groups: analgesics only, Rowatinex with analgesics, and tamsulosin with analgesics. For ureter stones less than 4 mm in diameter, their excretion was accelerated by both Rowatinex and tamsulosin. The use of these two treatments also decreased the amount of analgesics required and it was concluded that they should be considered as adjuvant regimes (Bak et al., 2007).

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Get Rid of Gallstones Naturally

Get Rid of Gallstones Naturally

One of the main home remedies that you need to follow to prevent gallstones is a healthy lifestyle. You need to maintain a healthy body weight to prevent gallstones. The following are the best home remedies that will help you to treat and prevent gallstones.

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