Oh

Dihydrocarvonic acid

FIGURE 8.5 Proposed metabolic pathway of (R)-(-)- and (S)-(+)-carvone in healthy volunteers. (Adapted from Engel, W., 2001. J. Agric. Food Chem, 49: 4069-4075; Jahrmann, R., 2007. Metabolismus von Monterpenen und Sesquiterpenen in Mensch und Säugetier: Bedeutung für die pharmazeutische Praxis. MPharm. diploma thesis, University of Vienna, Austria.)

microsomes, however, only 1,4-cineole 2 hydroxylation could be observed indicating species-related differences in 1,4-cineole metabolism (Miyazawa et al., 2001a) (Figure 8.6).

8.2.6 1,8-Cineole

1,8-Cineole, a monoterpene cyclic ether which is also named eucalyptol, is widely distributed in plants and is found in high concentrations in the essential oil of Eucalyptuspolybractea. It is extensively used in cosmetics, for cough treatment, muscular pain, neurosis, rheumatism, asthma, and urinary stones (Wichtel, 2002). Using rat liver microsomes, 1,8-cineole is predominantly converted to 3-hydroxy-1,8-cineole, followed by 2- and then 9-hydroxycineole (Miyazawa et al., 2001b). As seen in Figure 8.7, in human liver microsomes, however, only the 2-hydroxy- and 3-hydroxy products

FIGURE 8.6 Proposed metabolism of 1,4-cineole in rabbits and in rat and human liver microsomes. (Adapted from Asakawa, Y., M. Toyota, and T. Ishida, 1988. Xenobiotica, 18: 1129-1134; Miyazawa, M. et al., 2001a. Xenobiotica, 31: 713-723; Jahrmann, R., 2007. Metabolismus von Monterpenen und Sesquiterpenen in Mensch und Säugetier: Bedeutung für die pharmazeutische Praxis. MPharm. diploma thesis, University of Vienna, Austria.)

FIGURE 8.6 Proposed metabolism of 1,4-cineole in rabbits and in rat and human liver microsomes. (Adapted from Asakawa, Y., M. Toyota, and T. Ishida, 1988. Xenobiotica, 18: 1129-1134; Miyazawa, M. et al., 2001a. Xenobiotica, 31: 713-723; Jahrmann, R., 2007. Metabolismus von Monterpenen und Sesquiterpenen in Mensch und Säugetier: Bedeutung für die pharmazeutische Praxis. MPharm. diploma thesis, University of Vienna, Austria.)

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Aromatherapy Ambiance

Aromatherapy Ambiance

Aromatherapy, a word often associated with calm, sweet smelling and relaxing surroundings. Made famous for its mostly relaxing indulgent  feature, using aromatherapy has also been known to be related to have medicinal qualities.

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