Amylin Pramlintide

Amylin is a peptide secreted normally from the pancreas in equimolar amounts with insulin after a meal. It is thought to regulate gastric motility and the release of carbohydrates into the absorptive surfaces of the gut. Pramlintide is an amylin mimetic injected subcutaneously with meals, initially approved to be given with insulin in type 1 diabetic patients. The effect is usually modest to negligible, but anecdotal experience indicates that an occasional brittle diabetic patient may experience dramatic improvement. Pramlintide is now also used in type 2 patients with or without insulin because of its mild effect in limiting food intake and causing weight loss. Pramlintide is therefore used as a tertiary agent when other, more widely used drugs are not fully efficacious.

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