Anaphylaxis

Anaphylaxis has been traditionally defined as an acute, systemic, immediate hypersensitivity reaction produced by IgE-mediated degranulation of mast cells and basophils (Lieberman, 1998). The term anaphylactoid has referred to a clinically similar event not mediated by IgE-induced mast cell and basophil degranulation. An alternative classification by the World Allergy Organization (Johansson et al., 2004) eliminates anaphylactoid and refers to all events as anaphylactic, subdividing them into immunologic and nonimmunologic episodes. Immunologic episodes are then further subdivided into those caused by IgE-medi-ated mast cell and basophil degranulation and those resulting from other immunologic processes. An example of a non-IgE immunologically mediated event is a transfusion reaction. An example of a nonimmunologic event is a reaction to the administration of radiocontrast that can directly degranulate mast cells and basophils without intervening IgE.

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Curing Eczema Naturally

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