Baclofen

A GABA-B receptor agonist, baclofen has long been used as an antispasmodic. Only more recently has baclofen been investigated as a treatment for alcohol dependency. In a modest controlled trial of 1 month, baclofen was efficacious in achievement of total abstinent days compared with placebo (Addolorato et al., 2002). A follow-up study demonstrated efficacy in 84 patients with cirrhosis of the liver in maintaining abstinence (71% baclofen vs. 29% placebo) (Addolorato et al., 2007). There is potential for abuse of baclofen and withdrawal reactions, including delirium, which underscores the need for further research (Kanzler et al., 2009).

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