Burden of Disease

Colorectal cancer is the fourth most common cancer in the United States and is the second leading cause of cancer deaths. In 2009, an estimated 49,920 people died of colorectal cancer, with the disease newly diagnosed in more than 146,000 patients. Incidence is low until age 45, after which the incidence increases with each year of life. A 50-year-old person has a 5% chance of having colon cancer and a 2.5% chance of dying of the disease (Pignone et al., 2002b). The colorectal cancer mortality rate rises 10 years after the incidence rises, and the stage at diagnosis influences prognosis. The estimated 5-year survival falls from 90% for Dukes stage A (localized) cancers to 8% in Dukes stage D cancers (presence of distant metastases). Risk factors for colorectal cancer include a first-degree relative with a history of colorectal cancer, a family history of hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis, and patients with ulcerative colitis. However, most cases occur in persons of average risk.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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