Contraindications

Absolute

Prior cryotherapy sensitivity Vascular compromise Complication nonacceptance Steroid therapy Melanoma Invasive skin cancer Need for tissue diagnosis Expected poor wound healing

Relative*

Hepatitis B and C Mononucleosis Leukemia Lymphoma Myeloma Systemic lupus Nephritic syndrome Nephrotic syndrome Macroglobulinemia Rheumatoid arthritis

*High-risk of cryoglobulins.

more extensive than expected and more likely to recur. The vermillion border, periorbital area, and areas overlying cutaneous nerves present confounding variables to safe application of a cryogen for therapy.

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