Creutzfeldt Jakob Disease

Creutzfeldt-Jakob disease (CJD) is a very rare type of dementia associated with prion infection in the brain. It is characterized by unusually rapid progression. Rapid cognitive decline suggests the diagnosis of CJD. Myoclonus, fatigue, and visual problems are associated symptoms. Precise diagnosis requires a brain biopsy, but characteristic CSF and EEG findings are helpful to increase diagnostic certainty. Iatro-genic CJD occur when prion-contaminated tissue is grafted (dura mater, cornea) or injected (human growth hormone, pituitary gonadotropins) (Prusiner, 2001).

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